Cox proportional hazards modeling assessed DAI's prognostic value for 3-year survival. Separate ordinal logistic models assessed DAI's prognostic value for the following scores: (1) hospital-discharge Functional Independence Measure, (2) long-term Glasgow Outcome Scale-Extended, and (3) long-term Quality of Life after Brain Injury-Overall Scale. Exclusion criteria included penetrating TBI or prior neurologic condition. Inclusion criteria were positive head computed tomography with brain MRI within 2 weeks of admission. This retrospective single center cohort included adult trauma patients (age > 17 years) admitted from 2006 to 2012 with TBI. 1 From the Section of Surgical Sciences, Division of Trauma and Surgical Critical Care, Departments of Surgery and Neurosurgery (S.S.H., M.A.S., J.C.S., M.F.M., M.B.P.), Vanderbilt Brain Institute, Vanderbilt Center for Health Services Research, Vanderbilt University Medical Center, Nashville, Tennessee College of Medicine (S.S.H.), University of Tennessee Health Science Center (UTHSC), Memphis, Tennessee Department of Communication Sciences and Disorders (L.D.W.), Oxley College of Health Sciences, The University of Tulsa, Tulsa, Oklahoma Department of Hearing and Speech Sciences (L.D.W., M.B.P.), Department of Biostatistics (L.W.), Vanderbilt University School of Medicine (D.A.L., J.C.S., A.B., S.P., M.A.D., M.B.P.), Nashville, Tennessee Department of Emergency Medicine (D.A.L.), San Antonio Military Medical Center, Fort Sam Houston, Texas Vanderbilt University (M.A.S.) Meharry Medical College, Nashville, Tennessee (M.A.S.) Department of Radiology and Radiological Sciences (A.B., S.P., M.A.D.), Vanderbilt University Medical Center, Nashville, Tennessee Department of Neurology (S.M.), University of Massachusetts Medical School, University of Massachusetts Medical Center, Worcester, Massachusetts and Surgical Service, General Surgery Section, Geriatric Research, Education and Clinical Center Service, Department of Veterans Affairs Medical Center (M.B.P.), Tennessee Valley Health Care System, Nashville, Tennessee.ĭetermine the prognostic impact of magnetic resonance imaging (MRI)-defined diffuse axonal injury (DAI) after traumatic brain injury (TBI) on functional outcomes, quality of life, and 3-year mortality.
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